Millennium School is an innovation lab exploring the intersection of Developmental Science and Adolescent Education in the heart of San Francisco. In partnership with professors from leading universities, Millennium is developing an integrated educational program based on neuroscience and developmental psychology. These educators have convened to create a model middle school that implements best practices for holistic student development, translating leading research and experiential learning techniques into practical application. The program combines integrated academics with self-discovery and real-word application through student-centered projects. Beyond operating the lab school, Millennium seeks to disseminate its whole-student development methodology through professional development programs for teachers. The result is an integrated learning organization exploring well-being in education for the 21st century.